发明名称 |
COMPOUNDS HAVING A FUSED, BICYCLIC MOIETY FOR BINDING TO THE MINOR GROOVE OF DSDNA |
摘要 |
The present invention is directed to the means by which to alter the binding affinity and/or specificity of a compound with a sequence of DNA in the minor groove of a double-strand thereof. More particularly, the present invention is directed to a synthetic and/or non-naturally occurring compound (e.g., an analog of a polyamide oligomer or polymer) which contains at least one hydrogen bond donor moiety and at least one hydrogen bond acceptor moiety, wherein the latter moiety or "building block" has a fused, bicyclic structure which is heteroaromatic, said structure having a heteroatom therein which acts as a hydrogen bond acceptor to bind guanine in the minor groove of the dsDNA sequence, and which is incapable of forming a tautomer. In one particular embodiment of the synthetic and/or non-naturally occurring compound, the fused, bicyclic structure occupies an initial or first terminal position within the compound. |
申请公布号 |
WO2004099131(A2) |
申请公布日期 |
2004.11.18 |
申请号 |
WO2004US13285 |
申请日期 |
2004.04.29 |
申请人 |
PHARMACIA CORPORATION;PHILLION, DENNIS, P.;BASHKIN, JAMES, K. |
发明人 |
PHILLION, DENNIS, P.;BASHKIN, JAMES, K. |
分类号 |
C07D;C07D235/04;C07D401/00;C07D403/02;C07H19/04;C07H21/04;C12Q1/68 |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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