发明名称 |
NUCLEOSIDE DERIVATIVE, MODIFIED OLIGONUCLEOTIDE, METHOD FOR THEIR SYNTHESIS AND APPLICATIONS THEREOF |
摘要 |
New class of metallated nucleoside and nucleotide conjugates containing metallacarborane cage is provided, also oligonucleotides containing metallacarborane modification are disclosed. Nucleosides, nucleotides and oligonucleotides containing metallacarborane cage can be used among others as modified primers in amplification of RNA and DNA, antisense drugs, boron carriers for BNCT, radiopharmaceuticals bearing a range of isotopes useful in different types of radiotherapy, molecular probes, elements of biosensors, materials for nanotechnology and others. |
申请公布号 |
WO2004096824(A2) |
申请公布日期 |
2004.11.11 |
申请号 |
WO2004PL00030 |
申请日期 |
2004.04.30 |
申请人 |
CENTRUM MIKROBIOLOGII I WIRUSOLOGII POLSKIEJ AKADEMII NAUK;LESNIKOWSKI, ZBIGNIEW, J.;OLEJNICZAK, AGNIESZKA |
发明人 |
LESNIKOWSKI, ZBIGNIEW, J.;OLEJNICZAK, AGNIESZKA |
分类号 |
C07H19/00;C07H19/04;C07H21/00 |
主分类号 |
C07H19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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