| 发明名称 |
METHODS FOR PRODUCTION OF RECOMBINANT UROKINASE |
| 摘要 |
Highly efficient methods of producing properly folded recombinant urokinase are provided. Denatured recombinant pro-urokinase is refolded by first solubilizing the protein with a chaotroph at high pH, followed by refolding in the presence of reduced concentrations of chaotroph while the pH is slowly reduced. |
| 申请公布号 |
WO2004094344(A2) |
申请公布日期 |
2004.11.04 |
| 申请号 |
WO2004US11792 |
申请日期 |
2004.04.16 |
| 申请人 |
PROTEOMTECH, INC.;LIN, XINLI |
发明人 |
LIN, XINLI |
| 分类号 |
C07C;C07K1/02;C07K1/14;C07K1/16;C07K1/18;C07K1/20;C07K1/22;C07K1/36;C12N9/12;C12N9/72 |
主分类号 |
C07C |
| 代理机构 |
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