发明名称 |
RISEDRONATE SODIUM HAVING A VERY LOW CONTENT OF IRON |
摘要 |
<p>The present invention relates to a method of making risedronate sodium substantially free of iron including the steps of refluxing, especially with mechanical agitation, a combination of risedronic acid, a sodium base, especially sodium hydroxide, and an iron-reducing amount of EDTA in a liquid that is water, a lower alkanol, or, especially, a mixture of a lower alkanol and water; and isolating risedronate sodium substantially free of iron from the combination.</p> |
申请公布号 |
WO2004065397(A1) |
申请公布日期 |
2004.08.05 |
申请号 |
WO2004US01136 |
申请日期 |
2004.01.16 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;LIFSHITZ-LIRON, REVITAL;LIDOR-HADAS, RAMI;SASSON, NISSM;LIFSHITZ, IGOR |
发明人 |
LIFSHITZ-LIRON, REVITAL;LIDOR-HADAS, RAMI;SASSON, NISSM;LIFSHITZ, IGOR |
分类号 |
C07F9/59;(IPC1-7):C07F9/59 |
主分类号 |
C07F9/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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