POLYIONIC ORGANIC ACID FORMULATIONS

摘要

The present invention provides a nucleic acid transfection composition comprising a polyionic organic acid and a nucleic acid. Preferably, the polyionic organic acid is a dye. Efficient methods are also provided for administering the compositions, increasing the transfection efficiency in a cell (e.g., secretory gland cell), and using the compositions as nucleic acid stabilizers to prevent in vivo and in vitro nucleic acid degradation, thus increasing the half-life and shelf life of a nucleic acid.