摘要 |
This invention relates to a method for treating an angiogenesis-related disease. The method includes administering to a subject in need thereof an effective amount of a piperazinedione compound having the formula: In the above formula, each of <custom-character file="US20040132738A1-20040708-P00001.TIF" wi="20" he="20" id="custom-character-00001"/> and <custom-character file="US20040132738A1-20040708-P00002.TIF" wi="20" he="20" id="custom-character-00002"/>, independently, is a single bond or a double bond; A is H or CH(R<a>R<b>) when <custom-character file="US20040132738A1-20040708-P00001.TIF" wi="20" he="20" id="custom-character-00003"/> is a single bond, or C(R<a>R<b>) when <custom-character file="US20040132738A1-20040708-P00001.TIF" wi="20" he="20" id="custom-character-00004"/> is a double bond; Z is CH(R<c>R<d>) when <custom-character file="US20040132738A1-20040708-P00002.TIF" wi="20" he="20" id="custom-character-00005"/> is a single bond, or C(R<c>R<d>) when <custom-character file="US20040132738A1-20040708-P00002.TIF" wi="20" he="20" id="custom-character-00006"/> is a double bond; each of R1 and R2, independently, is H, C(O)R<e>, C(O)OR<e>, C(O)NR<e>R<f>, or SO2R<e>; and each of R<a>, R<b>, R<c>, R<d>, R<e>, and R<f>, independently, is H, C1-C6 alkyl, aryl, heteroaryl, C3-C8 cycloalkyl, or C3-C8 heterocycloalkyl; or R<a >and R<b >taken together are C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, or heteroaryl; or R1 and R<a >or R1 and R<b >taken together are C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, or heteroaryl; provided that one of R<c >and R<d >is aryl or heteroaryl.
|