发明名称 |
INDUCTION OF TOLERANCE THROUGH ORAL ADMINISTRATION OF A THERAPEUTIC AGENT COUPLED TO A TRANSPORTING AGENT |
摘要 |
<p>The present invention is directed toward a method for the induction of tolerance to a foreign transgene or a self-antigen in an animal host by administration of a composition to an animal host via a natural gastrointestinal pathway. Additionally, the present method can eliminate a pre-existing immune response in an animal host. The composition administered when carrying out the method achieves widespread distribution, systemic expression and sustained delivery of a genetic material in an animal host. More particularly, the invention discloses a method useful for both eliciting tolerance and for abrogation of a pre-existing immune response by oral administration of a genetic material.</p> |
申请公布号 |
WO2004054620(A1) |
申请公布日期 |
2004.07.01 |
申请号 |
WO2003CA01970 |
申请日期 |
2003.12.18 |
申请人 |
NEOX, INC. |
发明人 |
HORTELANO, GONZALO;VARGAS, ANDREW, GOMEZ |
分类号 |
A61K9/50;A61K47/48;A61K48/00;A61P3/10;A61P7/04;A61P21/04;A61P31/00;A61P31/18;A61P35/00;A61P43/00;(IPC1-7):A61K47/48 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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