发明名称 |
Method for identifying MHC-presented peptide epitopes for T cells |
摘要 |
Described are three basic components: (1) methods for the display of functional MHC molecules with covalently attached antigenic peptides on the surface of baculovirus and baculovirus infected insect cells; (2) methods for the identification and physical isolation of baculovirus or baculovirus infected insect cells bearing a displayed MHC/peptide combination that is recognized by a particular T cell antigen receptor; and (3) methods for producing libraries of baculovirus or baculovirus infected insect cells displaying a particular MHC molecule and many different potential antigenic peptides.
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申请公布号 |
US2004110253(A1) |
申请公布日期 |
2004.06.10 |
申请号 |
US20030640881 |
申请日期 |
2003.08.13 |
申请人 |
KAPPLER JOHN W.;CRAWFORD FRANCES G.;MARRACK PHILIPPA |
发明人 |
KAPPLER JOHN W.;CRAWFORD FRANCES G.;MARRACK PHILIPPA |
分类号 |
C07H21/04;C07K14/74;C12N5/06;C12N15/00;C12N15/09;C12N15/10;C12N15/63;C12N15/86;G01N;G01N33/53;G01N33/569;G01N33/68;(IPC1-7):C07H21/04 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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