MIP-1alpha AND GM-CSF AS ADJUVANTS OF IMMUNE RESPONSE

摘要

The present invention features methods to substantially increase the immunogenicity of a vaccine, preferably a DNA vaccine, and involves providing a mammal with a vaccine regimen, which include at least one immunogen, GM-CSF, and MIP- I alpha in the absence of exogenous IL-4. The methods of the present invention are useful for the prevention, treatment, and reduction of various pathological states, including for example, cancer, microbial infections, autoimmune diseases, tissue rejection, and allergic reactions.