A process for the preparation of s (-) amlodipine salts

摘要

Preparation of S(-) amlodipine salts (I) involves: (1) reacting S(-) amlodipine base with a solution of an acid in the presence of an organic solvent at room temperature; and (2) adding water to obtain the product in solid form. Preparation of S(-) amlodipine salts of formula (I) involves: (1) reacting S(-) amlodipine base with a solution of an acid in the presence of an organic solvent at room temperature; and (2) adding water to obtain the product in solid form. [Image] R : benzene sulfonic acid, succinic acid, maleic acid, oxalic acid or para-toluene sulfonic acid. ACTIVITY : Cardiovascular-Gen.; Hypotensive; Antianginal; Vasotropic. No biological data given. MECHANISM OF ACTION : Calcium Channel Blocker.