发明名称 |
In vitro process for the preparation of heart valve or vessel prothese |
摘要 |
<p>In vitro production of a homologous heart valve involves: (i) colonizing a biodegradable carrier with homologous fibroblasts and/or myofibroblasts so as to give a connective tissue matrix; (ii) colonizing the matrix with endothelial cells; (iii) introducing the matrix into a pulsating flow chamber (e.g. in a bioreactor) where it is subjected to a (dis)continuous flow rate. An Independent claim is also included for a homologous heart valve with a connective tissue inner core covered with a layer of endothelial cells, the core having a collagen density of 43-55%, based on the matrix.</p> |
申请公布号 |
EP1077072(B8) |
申请公布日期 |
2004.04.14 |
申请号 |
EP20000108986 |
申请日期 |
2000.04.27 |
申请人 |
SYMETIS AG |
发明人 |
HOERSTRUP, SIMON P.;ZUEND, GREGOR, DR. |
分类号 |
A61F2/24;A61L27/18;A61L27/38;A61L27/50;C12N5/08;(IPC1-7):A61L27/38 |
主分类号 |
A61F2/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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