发明名称 |
Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them |
摘要 |
The present invention relates to compounds of formula I: wherein R<1>, R<2>, and R<3 >have the meanings indicated in the specification, which are valuable pharmaceutical active compounds for the therapy and prophylaxis of diseases such as cardiovascular disorders such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses, or atherosclerosis. Compounds of formula I have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for the preparation of compounds of formula I, methods of therapy and prophylaxis of the designated disease states and for the production of pharmaceuticals therefor, and pharmaceutical compositions which comprise at least one compound of formula I.
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申请公布号 |
US2004063690(A1) |
申请公布日期 |
2004.04.01 |
申请号 |
US20030674350 |
申请日期 |
2003.10.01 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
SCHINDLER URSULA;SCHONAFINGER KARL;STROBEL HARTMUT |
分类号 |
A61K31/505;A61K31/506;A61K31/5377;A61K31/541;A61K31/55;A61P1/16;A61P3/10;A61P7/02;A61P9/00;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P13/12;A61P15/00;A61P25/28;A61P43/00;C07D239/94;C07D401/04;C07D413/04;(IPC1-7):A61K31/55;A61K31/537;A61K31/517;C07D417/02;C07D413/02;C0743/02 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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