FUSED PROTEIN ELICITING IN VIVO ENHANCED ACTIVITY OF ERYTHROPOIETIN

摘要

FIELD: molecular biology, genetic and protein engineering. SUBSTANCE: invention relates to the fused protein eliciting in vivo the enhanced activity of erythropoietin. In the fused protein peptide fragment from carboxy-end of thrombopoietin amino acids 337-353 is fused with carboxy-end of human erythropoietin. Invention involves also nucleic acid encoding the fused protein and method for it preparing. The advantage of invention involves that the fused protein shows the significantly increased index half-life in vivo due to the enhanced level of carbohydrates being without loss of its activity that is typical for erythropoietin and it causes neither antigenicity in its application in human body. EFFECT: valuable medicinal properties of protein. 5 cl, 5 dwg, 6 ex