Process for stereoselective synthesis of 2-hydroxymethyl chromans

摘要

A process for the stereoselective synthesis of 2-hydroxymethyl-chromans of formula (II) is providedwhere R, R<1>, R<2 >and R<3 >are as defined herein. The compound of formula (II) is prepared using an optically active benzene compound of formula (I)where R<0 >is as defined herein. The 2-hydroxymethyl-chroman compounds of formula (II) are useful as intermediates for preparing a variety of medicinal agents.