| 摘要 |
The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4- carboxamide intermediat es useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo [4,5-C] quinoline 4-amines using such intermediates; an d, to the 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4 - carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo [4,5-C] quinoline 4-ami ne (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c]quinoline 4 - cyano and 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-carboxamide, and to the sa id intermediates.
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