<p>A sensor which is suitable for the detection of a negatively charged species and which comprises a monolayer attached to a metal surface, wherein the monolayer comprises, in order from the surface: (a) a metal-anchoring group; (b) a host portion comprising two or more binding groups, which groups are together capable of chelating to the negatively charged species; and (c) a detector group which is capable of undergoing a detectable change in electrochemical or optical properties upon binding of the negatively charged species by the host portion (b); the host portion (b) being connected to each of the metal anchoring group (a) and the detector group (c) by a direct bond or via a linking group. The metal surface may be on an electrode or may be the surface of a metal nanoparticle, the nanoparticle being either free in solution or assembled at an interface.</p>
申请公布号
WO2004008131(A1)
申请公布日期
2004.01.22
申请号
WO2003GB02988
申请日期
2003.07.10
申请人
ISIS INNOVATION LIMITED;BEER, PAUL, DEREK;DAVIS, JASON, JOHN