发明名称 |
METHOD OF TREATING AUTOIMMUNE DISEASES WITH INTERFERON-BETA AND IL-2R ANTAGONIST |
摘要 |
Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease i s multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease.</S DOAB> |
申请公布号 |
CA2490804(A1) |
申请公布日期 |
2004.01.08 |
申请号 |
CA20022490804 |
申请日期 |
2002.11.27 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC RET |
发明人 |
MARTIN, ROLAND;MCFARLAND, HENRY F.;WALDMANN, THOMAS;BIELEKOVA, BIBIANA |
分类号 |
A61K45/00;A61K31/7052;A61K35/30;A61K38/00;A61K38/21;A61K39/00;A61K39/395;A61P25/00;A61P37/02;C07K16/28 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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