| 摘要 |
PROBLEM TO BE SOLVED: To provide a method of detecting a biochemical sample making it possible to simplify detection processes by use of a new label for detection, in a way assuring good reproducibility, while not requiring much skill on the part of a measurer, increasing the accuracy of detection, and consisting of simple processes; and a detection chip. SOLUTION: Probe DNAs are aligned on a thin film of gold formed on the surface of a glass substrate, in such a way that the probe DNAs together form a loop structure, with their open terminals located on the thin film so that, when there is a target gene, hybridization occurs, releasing the loop structure. Thus, only the hybridized DNA probes can be selectively modified with fine ceramic particles; a light scattering method is applied to these to detect the hybridization through the observation of the intensity of light scattered by the particles. COPYRIGHT: (C)2004,JPO
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