发明名称 |
Enzyme inhibitors |
摘要 |
Diketoacids of Formula A are useful as inhibitors of viral polymerases. In particular hepatitis C virus RNA dependent RNA polymerase (HCV RdRp), hepatitis B virus polymerase (HBV pol) and reverse transcriptase of human immunodeficiency virus (HIV RT): The group R may be broadly chosen and is an organic moiety which contains 2 to 24 carbon atoms and includes an optionally cyclic or heterocyclic group in which the atom directly bonded to the adjacent carbonyl in the diketoacid is part of the ring structure.
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申请公布号 |
US2003207922(A1) |
申请公布日期 |
2003.11.06 |
申请号 |
US20020238246 |
申请日期 |
2002.09.10 |
申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA |
发明人 |
NEUNER PHILIPPE JEAN SIGFRIED;SUMMA VINCENZO |
分类号 |
A61K31/40;A61K31/42;A61K31/445;C07C59/76;C07C59/90;C07D207/32;C07D207/337;C07D211/34;C07D211/96;C07D213/30;C07D213/89;C07D249/18;C07D249/20;C07D261/12;C07D307/80;C07D333/28;C07D333/34;C07D333/36;C07D333/38;C07D333/60;C07D333/74;C07D401/12;C07D409/04;C07D495/04;(IPC1-7):A61K31/445;A61K31/401;A61K31/192 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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