| 摘要 |
<p>The invention relates to the treatment of sexual dysfunction using compounds suitable for topical administration. In one embodiment, the invention comprises methods for treating male and female sexual dysfunction which comprises topical administration to an individual in need of such treatment of a composition comprising a compound which attenuates Rho-kinase activity in an organ subject to sexual stimulation and a pharmaceutically acceptable carrier. In one embodiment, the compound comprises an inhibitor of the enzyme Rho-kinase. In other embodiments, compounds targeted to other enzymes involved in the Rho-kinase pathway are used. Also described are compositions and kits for performing the methods of the invention.</p> |
