Anticancer-forbindelser indeholdende cyclopentaquinazolinring

摘要

PCT No. PCT/GB95/01016 Sec. 371 Date Oct. 29, 1996 Sec. 102(e) Date Oct. 29, 1996 PCT Filed May 4, 1995 PCT Pub. No. WO95/30673 PCT Pub. Date Nov. 16, 1995Cyclopentaquinazoline of the formula (I): (I) wherein R1 is hydrogen, amino, C1-4 alkyl, C1-4 alkoxy, C1-4 hydroxyalkyl or C1-4 fluoroalkyl; wherein R2 is hydrogen, C1-4 alkyl, C3-4 alkenyl, C3-4 alkynyl, C2-4 hydroxyalkyl, C2-4 halogenoalkyl or C1-4 cyanoalkyl; Ar1 is phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl which may optionally bear one or two substituents selected from halogeno, hydroxy, amino, nitro, cyano, trifluoromethyl, C1-4 alkyl and C1-4 alkoxy; and wherein R3 is a group of the formula:-A1-Ar2-A2-Y1in which A1, A2, Y1 and Ar2 are defined in claim 1; or a pharmaceutically acceptable salt or ester there of are of therapeutic value particularly in the treatment of cancer.