发明名称 |
A PROCESS FOR MAKING MORPHINE-6-GLUCURONIDE OR SUBSTITUTED MORPHINE-6-GLUCURONIDE |
摘要 |
Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.
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申请公布号 |
CA2114838(C) |
申请公布日期 |
2003.10.14 |
申请号 |
CA19922114838 |
申请日期 |
1992.08.04 |
申请人 |
SALFORD ULTRAFINE CHEMICALS AND RESEARCH LIMITED |
发明人 |
SCHEINMANN, FEODOR;LUMBARD, KEITH W.;BROWN, RICHARD T.;MAYALARP, STEPHEN P.;CARTER, NEIL E. |
分类号 |
A61K31/4355;A61K31/485;C07D489/00;C07D489/02;C07G3/00;C07H;C07H1/00;C07H13/02;C07H13/04;C07H17/00;C07H17/02;C07H19/00;(IPC1-7):C07H13/00;C07H23/00;C07H7/033 |
主分类号 |
A61K31/4355 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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