SPERM-SPECIFIC CATION CHANNEL, CATSPER2, AND USES THEREFOR

摘要

Nucleic acid and protein sequences relating to a cation channel which is spe rm- specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 ge ne and protein are disclosed. Also provided are methods of in vitro fertilizati on and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosi ng and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.