| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for producing a monatin compound expectable as a sweetening component for sweeteners, foods and drinks on an industrial scale in high efficiency. <P>SOLUTION: An indoleacetic acid derivative having a proper protecting group is reacted with an acid halide of aspartic acid preferably in the presence of a base, the produced condensation product is subjected to decarbonation and deprotection to obtain a new stereoselectively synthesized ketone derivative such as 2-amino-5-(3- indolyl)-4-oxopentanoic acid, the product is cyanohydrinated preferably under a basic condition and the obtained cyanohydrin derivative is hydrolyzed under a basic condition to obtain a crude monatin compound. The objective monatin compound having high purity can be produced by converting the crude monatin compound into a derivative by a means such as the introduction of a protecting group, purifying the compound in the form of the derivative and removing the protecting group by deprotection reaction. The present invention provides an excellent method for the production of a monatin compound (monatin or its steric isomer), a method for the efficient production of an important production intermediate for the former method and the important new intermediate produced by the method. <P>COPYRIGHT: (C)2003,JPO |
