PREVENTIVE OR REMEDY FOR PRURITUS

摘要

A pruritus preventive or remedy which contains as an active ingredient either a tricyclic compound represented by the following formula I: I [wherein R1 is hydrogen, unsubstituted lower alkyl, unsubstituted lower alkoxy, or halogeno X1-X2-X3 is CR5=CR6-CR7=CR8, NOm=CR6-CR7=CR8, CR5=CR6-NOm=CR8, CR5=CR6-CR7=NOm, CR5=CR6-O, CR5=CR6-S, O-CR7=CR8, S-CR7=CR8, or O-CR7=N and Y is -CH2S-, -CH2SO-, -CH2SO2-, -CH2O-, -CH=CH-, -CH2p-, -SCH2-, -SOCH2-, -SO2CH2-, or -OCH2-] or a pharmaceutically acceptable salt of the compound. This application belongs to the medicinal field.