| 摘要 |
A process for the preparation of 2-[alkyl(aryl)]sulfonylbenzene sulfonyl chlorides of the formula (I), in which R is alkyl or aryl substituted at the ortho or meta positions with alkyl, aryl, NHAc or alkoxy, comprising the ste ps of: a) reacting 2-chloronitrobenzene, 2-fluoronitrobenzene or 2- bromonitrobenzene with a compound of the following formula: RSO2-M+ wherein R is defined above; and M is sodium, potassium, lithium, ammonium or quaternar y ammonium, in a polar aprotic solvent at a temperature of about 50 to 190~C; b) reacting the material prepared in step (a) with hydrogen at a pressure of about 20 to about 60 psi in a polar aprotic solvent at a temperature of abou t 20 to about 60~C; and c) diazotizing the material prepared in step (b) with sodium nitrite in the presence of hydrochloric acid and reacting the resulti ng diazonium salt with sulfur dioxide in the presence of copper (I) or copper (II) compounds or a mixture thereof, in water.
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