2-PHENYL BENZIMIDAZOLES AND IMIDAZO-[4,5]-PYRIDINES AS CDSI/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER

摘要

2−Aryl substituted benzimidazoles and imidazo[4,5]pyridines of formula (I) are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. wherein W is COOH, −(CO)NHR?1¿, or −(SO=¿2?)NHR?1¿ R?1¿ is H or C¿1−4?alkyl; Q is N or CH; R¿a? and R¿b? are H or halogen; Y, Y¿1? and Y¿2? are independently selected from N and C−R¿c? with the proviso that 0, 1 or 2 of Y, Y¿1? and Y¿2? are N and at least 2 of R¿c? must be hydrogen; R¿c? are independently selected from the group consiting of −H, −OH, −C¿1−6?alkyl, −SCF¿3?, halo, −CF¿3? and −OCF¿3?; Z is selected from the group consisting of O, S, SO, SO¿2?, SO¿2?NR?2¿, NR?2¿SO¿2?, NH, CONR?2¿, piperazin−diyl or a covalent bond; R?2¿ is H or C¿1−4?alkyl; AR¿1? is an aromatic group as defined in the claims.