发明名称 |
METHOD FOR PREPARING SALTS OF ASPARTAME FROM N-PROTECTED ASPARTAME |
摘要 |
Method for preparing a salt of aspartylphenylalanine methyl ester from N-protected aspartylphenylalanine methyl ester involving cleaving off the protective group by treatment with an acid, in the course of which, first of all, N-protected aspartylphenylalanine methyl ester is caused to react in an aqueous medium and in the presence of methanol at a temperature of from 0 to 80° C. with from 0.8 to 2 equivalents of acesulphamic acid for at least such a time that the conversion to the salt of aspartylphenylalanine methyl ester and acesulphamic acid has been completed to an adequate degree, and then the salt formed in the first step is isolated in precipitated form at a temperature of 30° C. or lower. |
申请公布号 |
EP0986575(B1) |
申请公布日期 |
2003.04.23 |
申请号 |
EP19980924673 |
申请日期 |
1998.05.25 |
申请人 |
HOLLAND SWEETENER COMPANY V.O.F. |
发明人 |
VAN SOOLINGEN, JACOB;BOESTEN, WILHELMUS, HUBERTUS, JOSEPH |
分类号 |
A23L27/30;C07K5/075 |
主分类号 |
A23L27/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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