The present invention features Ad6 vectors and a nucleic acid encoding a Met - NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependen t RNA polymerase region. The nucleic acid is particularly useful as a componen t of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against H CV.
申请公布号
CA2461380(A1)
申请公布日期
2003.04.17
申请号
CA20022461380
申请日期
2002.10.10
申请人
MERCK & CO., INC.;ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
发明人
SHIVER, JOHN W.;NICOSIA, ALFREDO;KASLOW, DAVID C.;LAHM, ARMIN;BETT, ANDREW J.;LUZZAGO, ALESSANDRA;EMINI, EMILIO A.;CORTESE, RICCARDO;COLLOCA, STEFANO
