| 摘要 |
The present invention provides methods for non-invasive localized delivery o f biologically active molecules, comprising packaging a molecule(s) of interes t inside a thermosensitive particle, administering said particles to a subject , and inducing localized release of said molecules from said particles using a focused heat source. The thermosensitive particles may be thermosensitive polymer nanoparticles or thermosensitive liposomes. The particles may be delivered to a subject by any technique, including infusion. The molecules m ay be released from the particles using any method which induces localized hyperthermia, including focused ultrasound.
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