发明名称 |
MYCOBACTERIAL ANTIGENS EXPRESSED DURING LATENCY |
摘要 |
A method is provided for identifying mycobacterial genes that are induced or up-regulated under culture conditions that are nutrient-starving and which maintain mycobacterial latency, said conditions being obtainable by batch fermentation of a mycobacterium for at least 20 days post-inoculation, when compared with culture conditions that are not nutrient-starving and which support exponential growth of said mycobacterium. Said induced or up-regulated genes form the basis of nucleic acid vaccines, or provide targets to allow preparation of attenuated mycobacteria for vaccines against mycobacterial infections. Similarly, peptides encoded by said induced or up-regulated genes are employed in vaccines. In a further embodiment, the identified genes/peptides provide the means for identifying the presence of a mycobacterial infection in a clinical sample by nucleic acid probe or antibody detection. |
申请公布号 |
WO03004520(A2) |
申请公布日期 |
2003.01.16 |
申请号 |
WO2002GB03052 |
申请日期 |
2002.07.04 |
申请人 |
MICROBIOLOGICAL RESEARCH AUTHORITY;JAMES, BRIAN, WILLIAM;MARSH, PHILIP;HAMPSHIRE, TOBIAS |
发明人 |
JAMES, BRIAN, WILLIAM;MARSH, PHILIP;HAMPSHIRE, TOBIAS |
分类号 |
G01N33/53;A61K35/76;A61K38/00;A61K38/55;A61K39/00;A61K39/04;A61K39/39;A61K39/395;A61K45/00;A61K48/00;A61P31/04;C07K14/35;C07K16/40;C12N1/21;C12N9/00;C12N9/99;C12N15/09;C12N15/31;C12Q1/06;C12Q1/68;C12R1/32;G01N33/58;G01N37/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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