发明名称 CRYSTALLINE MODIFICATIONS B AND C OF 1-(2,6-DIFLUORO-BENZYL)-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE AND PHARMACEUTICAL COMPOSITION
摘要 FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel modifications B and C of compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carbox-amide of the formula (I) and pharmaceutical composition showing anticonvulsant activity and comprising said crystalline modifications. Modifications exhibit higher rate of dissolving in water and gastric juice that is important in their using in therapeutic aims, for example, in acute attack of epilepsy. EFFECT: valuable medicinal properties of modifications. 14 cl, 1 tbl, 2 dwg, 3 ex
申请公布号 RU2194041(C2) 申请公布日期 2002.12.10
申请号 RU19990104299 申请日期 1998.06.08
申请人 NOVARTIS AG 发明人 PORTMANN ROBERT;KHOFMAJER URS KRISTOF;BURKKHARD ANDREAS;SHERRER VAL'TER;SHELAGEVICH MARTIN
分类号 A61K31/41;A61K31/4192;A61P25/08;C07D249/04;(IPC1-7):C07D249/04 主分类号 A61K31/41
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