| 摘要 |
organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel immunotherapeutic compounds of the formula: alpha where X means O- or where n has value 0, 1, 2 or 3; -(CnH2n)- means alkyl containing from 1 to 10 carbon atoms or monocycloalkyl containing up to 10 carbon atoms; R1 means hydrogen atom, lower alkyl or lower alkoxy-group; R2 means: (1) unsubstituted phenyl or naphthalene or phenyl or naphthalene substituted with one or more substitutes being each is taken independently among nitro-group, halogen atom, amino-group, amino-group substituted with alkyl containing 1-5 carbon atoms, alkyl containing up to 10 carbon atoms, cycloalkyl containing up to 10 carbon atoms, alkoxy-group containing up to 10 carbon atoms, cycloalkoxy-group containing up to 10 carbon atoms, phenyl or methylenedioxy-group; (2) pyridine; each of R3 and R4 taken separately means hydrogen atom; or R5 and R4 taken in common mean a bond carbon-carbon; Y means COZ, R5 or lower alkyl containing from 1 to 5 carbon atoms; Z means OH, -C=N or NR6R6, -R7; -OR7 means hydrogen atom or lower alkyl; and R6 means alkyl. These compounds are inhibitors of tumor necrosis R7-factor, nuclear factor kB and phosphodiesterase and can be used for control of cachexia, endotoxic shock, replication of retroviruses, asthma and inflammatory states. Invention relates to also a pharmaceutical composition based on these compounds and a method of decrease of levels of PHDE (phosphodiesterase), tumor necrosis alpha-factor (TNFalpha) and nuclear factor kB (NFkB). EFFECT: new immunotherapeutic compounds indicated above, valuable medicinal properties. 9 cl, 1 tbl
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