发明名称 |
RETINOID INDUCIBLE PROTEINS OF VASCULAR SMOOTH MUSCLE CELLS AND USES THEREOF |
摘要 |
The present invention relates to an isolated retinoid inducible serine carboxypeptidase proteins or polypeptides, and the nucleic acid molecules encoding such a protein or polypeptide. Nucleic acid constructs, expression systems and host cells containing those nucleic acid molecules, and antibodi es raised against the proteins or polypeptides are also disclosed. The present invention also relates to methods for detecting a vascular disease or disorder, inhibiting smooth muscle cell growth, treating vascular hyperplasi a, and inhibiting the activity of extracellular regulated kinase. The present invention also relates to a transgenic non-human animal lacking a gene encoding a retinoid inducible protein or polypeptide.
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申请公布号 |
CA2438827(A1) |
申请公布日期 |
2002.09.06 |
申请号 |
CA20022438827 |
申请日期 |
2002.02.22 |
申请人 |
UNIVERSITY OF ROCHESTER |
发明人 |
STREB, JEFFREY WILLIAMS;MIANO, JOSEPH MICHAEL;CHEN, JIYUAN |
分类号 |
C12N5/02;C12N9/64;(IPC1-7):C12N15/57;A61K48/00;A61P9/00;A61P21/00;A01K67/027;A61K38/17;C07K16/40;C12N9/48;G01N33/53;C12Q1/68 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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