METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS

摘要

To more efficiently provide CPT, which is a starting compound for irinotecan hydrochloride and various camptothecin derivatives, by a practically usable total synthesis, a means whereby 2'-amino-5'-hydroxypropiophenone corresponding to the AB cycle moiety of the camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE cycle moiety thereof can be efficiently produced and thus CPT and its derivatives can be stably supplied is provided.