| 摘要 |
<p>The present invention relates to methods and devices employed to control the onset of blood sugar levels below a predetermined minimum level over an extended period of time. The invention includes methods and devices for producing a therapeutic effect in a subject including placing a source of glucose or glucagon in a transdermal patch in transmitting relationship to an area of intact skin; and administering glucose or glucagon to the subject from the source through the area of intact skin for an extended period of time at a therapeutically effective rate for a substantial portion of the extended period of time to prevent the onset of a low blood sugar level in the subject. The methods and devices may include administering glucose or glucagon to the subject from the source through the area of intact skin for at least 4 hours, or longer, perhaps 24 hours or more, and are particularly well suited for administering glucose or glucagon to the subject from the source through the area of intact skin between usual sleeping hours. Additional therapeutic substances may also be administered to the subject from the source through the area of intact skin, including one or more nutritional supplements such as vitamins A, C, or D.</p> |
