发明名称 |
Verfahren zur Detektion von Methylierungszuständen zur toxikologischen Diagnostik |
摘要 |
The invention relates to a method for a toxicological diagnostic. According to the invention, a DNA sample is taken from an organism or a cell culture which has been exposed to a specific substance which is to be examined on account of its toxicological effect. The DNA contained in said sample is chemically pre-treated and the base sequence of a section of the modified DNA is determined. From there, a characteristic methylation state or a characteristic methylation model is determined for the sample. By comparison with data from methylation states of other samples, the effect of a substance on the organism or the cell culture is determined and/or compared to other substances in toxicological terms.
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申请公布号 |
DE10056802(A1) |
申请公布日期 |
2002.05.29 |
申请号 |
DE2000156802 |
申请日期 |
2000.11.14 |
申请人 |
EPIGENOMICS AG |
发明人 |
OLEK, ALEXANDER;PIEPENBROCK, CHRISTIAN;BERLIN, KURT |
分类号 |
C12N15/09;C12Q1/68;G01N33/50;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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主权项 |
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地址 |
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