发明名称 |
HUMAN ANTI-FACTOR IX/IXa ANTIBODIES |
摘要 |
The invention provides for the isolation, identification, synthesis, expression and purification of antibodies reactive with factor IX (FIX)/factor IXa (IXa). In particular aspects, the invention provides human antibodies reactive with the human FIX Gla domain. The invention further provides compositions especially pharmaceutical compositions, articles of manufacture, and methods of inhibiting the activation of-FIX and inhibiting FIX/IXa dependent coagulation. |
申请公布号 |
EP1107996(B1) |
申请公布日期 |
2002.05.22 |
申请号 |
EP19990943928 |
申请日期 |
1999.08.26 |
申请人 |
GENENTECH, INC. |
发明人 |
ADAMS, CAMELLIA, W.;DEVAUX, BRIGITTE;EATON, DAN, L.;HASS, PHILIP, E.;JUDICE, J., KEVIN;KIRCHHOFER, DANIEL;SUGGETT, SHELLEY |
分类号 |
G01N33/50;A61K38/00;A61K39/395;A61P7/02;A61P9/02;A61P9/10;A61P11/00;A61P39/02;C07K16/36;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/13;C12N15/63;C12P21/02;C12P21/08;G01N33/15 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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