USE OF D-LEU DELTORPHIN FOR PROTECTION AGAINST ISCHEMIA AND REPERFUSION INJURY
摘要
A compound and method for using compound-D SEQ ID NO:1 to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
申请公布号
WO0230450(A1)
申请公布日期
2002.04.18
申请号
WO2001US00909
申请日期
2001.01.11
申请人
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION;ZYMOGENETICS, INC.
发明人
OELTGEN, PETER, R.;BISHOP, PAUL, D.;KINDY, MARK, S.;SANCHEZ, JUAN, A.