发明名称 |
HUMAN ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR SINGLE-CHAIN ANTIBODIES |
摘要 |
Human anti-epidermal growth factor receptor (EGFR) single-chain antibodies (scFvs) were isolated from a human IgM phage display library using purified epidermal growth factor receptor as antigen. Two isolates with different amino acid sequences were identified by ELISA as epidermal growth factor receptor-specific. the scFvs bind to the full length epidermal growth factor receptor and the truncated and/or mutated epidermal growth factor receptor on human cells. These anti-EGFR-scFvs are useful as therapeutic and/or diagnostic agents.
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申请公布号 |
WO0230984(A1) |
申请公布日期 |
2002.04.18 |
申请号 |
WO2001US31857 |
申请日期 |
2001.10.12 |
申请人 |
UAB RESEARCH FOUNDATION |
发明人 |
RAISCH, KEVIN, PAUL;CURIEL, DAVID, T.;BONNER, JAMES, ALAN |
分类号 |
C12N15/09;A61K39/395;A61K45/00;A61K51/00;A61K51/10;C07K16/28;(IPC1-7):C07K16/00;C07H19/00;C12P21/06;A01N43/04 |
主分类号 |
C12N15/09 |
代理机构 |
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