AMINOMETHYLPYRROLIDINE DERIVATIVES HAVING AROMATIC SUBSTITUENTS

摘要

This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R<1> is an optionally substituted aromatic group, a salt of the same or a hydrate of both. <CHEM> In the formula, R<2>, R<3>: hydrogen atom, an alkyl group; R<4>, R<5>, R<6>: hydrogen atom, hydroxyl group, a halogen atom, carbamoyl group, an alkyl group, an alkoxyl group, an alkylthio group; R<7>, R<8>: hydrogen atom, an alkyl group; R<9>: an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, an aryl group, a heteroaryl group, an alkoxyl group having from 1 to 6 carbon atoms, an alkylamino group; R<10>: hydrogen atom, an alkylthio group; R<11>: hydrogen atom, amino group, hydroxyl group, thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; X<1>: halogen atom, a hydrogen atom; A<1>: nitrogen atom, C-X<2>; X<2>: hydrogen atom, amino group, a halogen atom, cyano group, an halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; A<2>, A<3>:>C=C(-A<1>=)-N(-R<9>)-,>N-C(-A<1>=)=C(-R<9>)-; R<10> and R<9> or R<9> and X<2> may be integrated to form a ring structure; and Y: hydrogen atom, ester forming group.