| 发明名称 |
LACTAM COMPOUNDS AND THEIR USE AS INHIBITORS OF SERINE PROTEASES AND METHOD |
| 摘要 |
Lactam inhibitors are provided which have the structure (I), x is (a) or (b) wherein Y is O or S and R4 is (i), (ii) or R8 at least one of R1 and R2 is hydrogen, and R1, R2, R3, R5, R6, R7, and R8, are as defined herein. These compounds are inhibitors of tryptase and thus are useful in treating asthma. Methods for treating asthma and related diseases are also provided.
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| 申请公布号 |
CA2418995(A1) |
申请公布日期 |
2002.02.14 |
| 申请号 |
CA20012418995 |
申请日期 |
2001.07.20 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SLUSARCHYK, WILLIAM A.;ZHAO, GUOHUA;SUTTON, JAMES C., JR.;SEILER, STEVEN M.;LAWRENCE, R. MICHAEL;BISACCHI, GREGORY S. |
| 分类号 |
C07D223/12;A61K31/55;A61K38/00;A61K45/00;A61K45/06;A61P1/00;A61P1/04;A61P1/16;A61P7/02;A61P9/00;A61P9/10;A61P11/00;A61P11/02;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P27/02;A61P29/00;A61P35/00;A61P37/08;A61P43/00;C07D223/10;C07D401/12;C07D401/14;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D417/14;C07K5/06;C07K5/078;(IPC1-7):C07K5/078;A61K38/55 |
主分类号 |
C07D223/12 |
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