发明名称 |
CRYSTALLINE AND PURE MODAFINIL, AND PROCESS OF PREPARING THESAME |
摘要 |
The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone products of over-oxidation and other byproducts. The invention further provides new crystalline Forms II-VI of modafinil and processes for preparing them. Each of the new forms is differentiated by a unique powder X-ray diffraction pattern. The invention further provides pharmaceutical compositions containing novel modafinil Form s II-IV and VI. |
申请公布号 |
CA2416792(A1) |
申请公布日期 |
2002.02.07 |
申请号 |
CA20012416792 |
申请日期 |
2001.07.27 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
ARONHIME, JUDITH;SINGER, CLAUDE;GERSHON, NEOMI;LIEBERMAN, ANITA;CEAUSU, ARINA |
分类号 |
A61K;A61K31/165;C07C;C07C315/02;C07C315/06;C07C317/44;C30B7/00 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|