| 摘要 |
PURPOSE: A method for preparing optically pure (S)-β-hydroxy-γ-butyrolactone continuously is provided, to improve the purity and the production yield by using a catalyst and controlling the reaction conditions. CONSTITUTION: The method comprises the steps of adding a substituted carboxylic acid derivative dissolved in a solvent and hydrogen into a reactor charged with an inorganic oxide carrier where a noble metal catalyst is dipped, with a weight space velocity of 0.1-10 per hour at a stationary phase reactor temperature of 50-500 deg.C and a reaction pressure of 15-5,500 psig, wherein the molar ratio of the carboxylic acid derivative to hydrogen is 1-10, and the content of the carboxylic acid derivative in the solvent is 1-50 wt%. Preferably the noble metal catalyst is selected from Pd, Pt, Rh, Ir, Ru, Os and their mixtures; the solvent is selected from methanol, ethanol, n-propyl alcohol, isopropyl alcohol, dioxane, γ-butyrolactone, tetrahydrofuran, water and their mixtures; and the inorganic oxide carrier is selected from alumina, silica, silica-alumina, zirconia, titania, zeolite and their mixtures.
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