发明名称 |
Use of Fas ligand to suppress T-lymphocyte-mediated immune responses |
摘要 |
A method for inhibiting T-lymphocyte-mediated immune responses, including those directed against autologous and/or heterologous tissues, e.g., by a recipient mammal of a transplanted tissue, said method comprising providing the recipient mammal with Fas ligand. The Fas ligand may be provided to the recipient mammal by a variety of means, including by pump implantation or by transplantation of transgenic tissue expressing Fas ligand. Also provided is a method for diagnostic use of Fas ligand expression in improving transplantation success.
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申请公布号 |
US6325999(B1) |
申请公布日期 |
2001.12.04 |
申请号 |
US19980087195 |
申请日期 |
1998.05.29 |
申请人 |
UNIVERSITY TECHNOLOGY CORPORATION |
发明人 |
BELLGRAU DONALD;DUKE RICHARD C. |
分类号 |
C12N15/09;A01N1/02;A61K35/12;A61K35/76;A61K38/00;A61K39/395;A61K48/00;A61P3/08;A61P29/00;A61P37/00;A61P37/06;C07H21/04;C07K14/52;C07K14/705;C12N5/10;C12P21/02;C12P21/08;C12R1/91;(IPC1-7):A01N63/00;A01N37/18;C12P21/06;C12N5/00;C12N5/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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