A method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of hiv envelope proteins

摘要

The current invention relates to methods of generating immunogens that elicit broadly neutralizing antibodies which target regions of viral envelope proteins such as the gp 120/gp41 complex of HIV-1. More specifically, the current invention involves using stabilizing peptides modeling the alpha-helical regions of the ectodomain of the HIV-1 transmembrane protein to stabilize fusion-active intermediate structures which can be used as vaccine immunogens.