发明名称 |
TASTE MASKING RAPID RELEASE COATING SYSTEM |
摘要 |
<p>The invention relates to a tablet which rapidly releases a drug in the stomach of a patient comprising: a drug-containing core; a taste masking layer wherein said taste masking layer increases the weight of the core by between 5 and 100 percent by weight composed of a material which is generally insoluble in saliva at a neutral to basic pH and completely soluble in saliva at a pH of less than 6.5; and a spacing layer surrounding said core, wherein said spacing layer increases the weight of the core by between 5 and 100 percent by weight and substantially completely sequestering said core from said taste masking layer and being capable of rapidly exposing said core when exposed in the stomach of a patient; said taste masking layer preventing exposure of said spacing layer in the mouth of a patient for a period of at least 20 seconds after being placed into the mouth and being capable of rapidly exposing said spacing layer when in the stomach of a patient; wherein the taste-masked formulation disintegrates in the mouth of a patient in less than 90 seconds to form a suspension of particles; wherein the coated drug-containing core generally has a diameter of no larger than 1,500 micrometer.</p> |
申请公布号 |
EP1133282(A1) |
申请公布日期 |
2001.09.19 |
申请号 |
EP19990962868 |
申请日期 |
1999.11.24 |
申请人 |
CIMA LABS INC. |
发明人 |
HOLT, KRIS, E.;KHANKARI, RAJENDRA, K.;HONTZ, JOHN |
分类号 |
A61K9/28;A61K9/00;A61K9/50;A61K47/00;(IPC1-7):A61K9/14 |
主分类号 |
A61K9/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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