KONJUGAT ENTHALTEND EIN GERADKETTIGES ORGANISCHES POLYMER MIT GEBUNDENEN SULFATIERTEN GLUKOSAMINOGLUKANEN WIE ZUM BEISPIEL HEPARIN, SEINE HERSTELLUNG, VERWENDUNG UND EIN ENTSPRECHENDES SUBSTRAT

摘要

PCT No. PCT/SE92/00672 Sec. 371 Date May 25, 1994 Sec. 102(e) Date May 25, 1994 PCT Filed Sep. 25, 1992 PCT Pub. No. WO93/05793 PCT Pub. Date Apr. 1, 1993.The present invention relates to a water-soluble conjugate having antithrombin-binding activity comprising a substantially straight-chained organic polymer backbone having at least 30 molecules of sulfated glycosaminoglycans distributed along the polymer backbone, wherein the sulfated glycosaminoglycans are attached to the polymer backbone at a single point of attachment which is not responsible for the antithrombin-binding activity. The present invention also relates to a surface having antithrombin-binding properties prepared with the conjugate and methods of preparing said conjugate and said surface.