Shank proteins and nucleotides encoding Shank proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by Shank proteins. A method is further provided for identifying a compound that modulates cytoskeletal stability mediated by Shank proteins. A method is provided for identifying a compound that modulates synaptic receptor localization or synaptic receptor clustering, which are mediated by Shank proteins.
申请公布号
WO0078921(A3)
申请公布日期
2001.08.09
申请号
WO2000US17322
申请日期
2000.06.23
申请人
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;MASSACHUSETTS GENERAL HOSPITAL;WORLEY, PAUL;TU, JIAN, CHENG;XIAO, BO;SHENG, MORGAN
发明人
WORLEY, PAUL;TU, JIAN, CHENG;XIAO, BO;SHENG, MORGAN