Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen

摘要

The invention relates to a method for producing 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones, especially 4-(4-pyridylmethyl)-1(2H)-phthalazinone, which is characterized by the reaction of phthalidyl-3-triphenylphosphonium salt with 4- pyridine aldehyde in the presence of a basic auxiliary agent, by the subsequent reaction with hydrazine hydrate and by the subsequent acid treatment, whereby this method avoids the technical safety and environmental problems posed by prior art methods.